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Sr. Director, Clinical Program Management

Kyverna Therapeutics is a patient-centered, clinical-stage biopharmaceutical company developing cell therapies for patients suffering from autoimmune diseases. Guided by our core values, Stay True to Why, Collaborate to Accelerate, Lead with Clarity, Boldly Innovative, and Own the Outcome, we are committed to transforming the future of treatment for autoimmune disease. Join us at the forefront of cell therapy innovation and help redefine what’s possible. Title: Sr. Director, Clinical Program Management Reports to: SVP, Clinical and Development Operations Location: Remote with up to 20% travel Kyverna is seeking a highly strategic and clinically focused Sr. Director, Clinical Program Management to lead cross-functional development activities supporting cell therapy programs in autoimmune indications. This individual will partner closely with Clinical Development, Clinical Operations, Medical Affairs, Biometrics, Regulatory, Safety, Technical Operations, and external partners to drive execution of complex global clinical programs from early development through registrational studies and potential commercialization. Responsibilities<div> <ul> <li>Translate program strategy into integrated timelines, milestones, and deliverables, ensuring coordination across all contributing functions</li> <li>Provide Project Management expertise and support to advance Kyverna’s novel engineered T cell therapy programs</li> <li>Manage one or more highly complex R&D programs and/or high-profile partnerships</li> <li>Results-oriented accountability for achievement of program timeline and deliverables</li> <li>Effectively communicate with project team members, Senior Leadership Team, Functional Heads, and key stakeholders</li> <li>Track and monitor key milestones and decision points to drive delivery of project objectives</li> <li>Contribute to PMO LT to develop tools for project governance and program timelines, as well as the communication of program KPIs, risks and achievements</li> <li>Manage the interfaces between functional areas and ensure effective handoff and communication between department functions to execute on important project milestones</li> <li>Lead cross-functional program management activities supporting autoimmune clinical development programs.</li> <li>Develop and maintain integrated clinical development plans, timelines, milestones, budgets, and risk management strategies across multiple functional areas.</li> <li>Drive execution and alignment across Clinical Development, Clinical Operations, Medical Affairs, Biometrics, Safety/Pharmacovigilance, Regulatory Affairs, Manufacturing, and Quality.</li> <li>Partner with Clinical and Medical leadership to support development strategy, indication prioritization, and lifecycle planning for assigned programs.</li> <li>Ensure program activities support regulatory milestones including INDs, protocol amendments, global health authority interactions, and potential BLA/MAA submissions.</li> <li>Partner with Clinical Operations to proactively identify enrollment, operational, and site-performance risks and implement mitigation strategies.</li> <li>Ensure seamless coordination between clinical and CMC activities supporting cell therapy manufacturing, supply planning, patient scheduling, and treatment logistics.</li> <li>Facilitate governance meetings, cross-functional team meetings, and executive program reviews.</li> <li>Collaborate with Clinical Research Scientists and Medical Directors on protocol strategy, clinical endpoints, efficacy measures, biomarkers, and patient-reported outcomes relevant to autoimmune studies.</li> <li>Support competitive intelligence activities and maintain awareness of evolving autoimmune treatment landscapes, clinical trial designs, and emerging therapies.</li> <li>Partner with Regulatory and Medical Writing teams to support preparation of briefing documents, regulatory submissions, investigator brochures, and clinical study reports.</li> <li>Establish and maintain program dashboards, KPIs, risk registers, and governance frameworks to ensure transparency and accountability.</li> <li>Drive continuous improvement of program management processes, tools, and reporting capabilities.</li> <li>Support budget forecasting, scenario planning, and resource prioritization across clinical programs.</li> </ul> Mentor and develop program management staff and contribute to building scalable development operations infrastructure.</div> Qualifications<div> <ul> <li>A minimum of a BA/BS and 15+ yrs in a Program/Project management supporting drug development is required, and an advanced degree (Ph.D., MS, MD) and/or PM Certification is preferred.</li> <li>Exceptional communication skills (in person and written word) and the ability to interact with a diverse group of individuals.</li> <li>Extensive experience managing and partnering with Contract Development and Manufacturing Organizations in the Cell and Gene Therapy space. Must have experience working on the sponsor side in Cell and Gene Therapy organizations; prior experience on the supplier side is considered a strong plus. </li> <li>Experience with gene or cell therapy development programs required.</li> <li>Experience applying the principles, concepts, practices, and standards of project management for drug development.</li> <li>The ability to understand and communicate scientific and business elements associated with Kyverna’s engineered T cell therapies is a must.</li> <li>Strong skills in management of external stakeholders and ability to influence and guide them toward decisions and outcomes that support Kyverna’s goals. </li> <li>Excellent interpersonal skills, ability to develop relationships with key stakeholders, good conflict management skills.</li> <li>Proven ability to proactively identify risks and drive resolution of issues.</li> <li>Proven track record for delivering projects on time and in full including release of product and regulatory milestones (i.e new drug and biologics licensure applications)</li> <li>Results and detail-oriented; self-motivated, ability to work with minimal supervision.</li> <li>Ability to perform and be adaptive in a fast-paced environment under tight deadlines.</li> <li>Strong analytical and problem-solving capabilities.</li> </ul> </div> The national base salary range for this position is $240K-$270K annually. This salary range is an estimate of what we reasonably expect to pay for this position, and the actual salary may vary based on various factors that may include but are not limited to quality and length of experience, education, geographic location and alignment with market data. This position is also eligible for bonus, benefits, and participation in the company’s stock plan.

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