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Senior Clinical Research Associate (Oncology Experience Required) - UK - FSP

When our values align, there's no limit to what we can achieve. At Parexel, we all share the same goal - to improve the world's health. From clinical trials to regulatory, consulting, and market access, every clinical development solution we provide is underpinned by something special - a deep conviction in what we do.Each of us, no matter what we do at Parexel, contributes to the development of a therapy that ultimately will benefit a patient. We take our work personally, we do it with empathy and we're committed to making a difference.Parexel are Senior Clinical Research Associates for UK based sponsor dedicated roles. Experience in oncology trials and RECIST criteria is essential. A minimum of 5 years' experience in CRO or Pharma trials environments is also essential.The Senior CRA will be responsible for data integrity, data quality and ensuring compliance with ICH GCP and local requirements at the site level. Monitoring will be conducted in line with the Study Monitoring Plan (SMP) and will be performed virtually for the majority of activities to supplement on site visit requirements. The Senior CRA will collaborate with the Site Manager to assure that the site complies with the protocol and is inspection ready and will coordinate with institutions and investigators at the local level.Some specifics about this advertised roleOversight of Monitoring Responsibilities and Study Conduct<ul><li>Ensuring regulatory, ICH-GCP and protocol compliance. Uses judgment and experience to evaluate overall performance of site and site staff and to provide recommendations regarding site-specific actions; immediately communicates/escalates significant issues to the project team and develops action plans. Maintains a working knowledge of ICH/GCP Guidelines or other applicable guidance, relevant regulations, and company Standard Operating Procedures (SOPs)/processes.</li><li>Verifies the process of obtaining informed consent has been adequately performed and documented for each subject as required.</li><li>Demonstrates diligence in protecting the confidentiality of each subject and assesses factors that might affect subject safety and clinical data integrity at an investigator site such as protocol deviation and violations and pharmacovigilance issues.</li><li>Per the Clinical Monitoring Plan (CMP) or SMP: Ability to conduct monitoring activities using different methods, (e.g., both on site and remote) where allowed by country regulations.</li><li>Conducts source document review and verification of appropriate site source documents and medical records. Verifies required clinical data entered in the Case Report Form (CRF) is accurate and complete.</li><li>Manages reporting of protocol deviations and appropriate follow up.</li><li>Applies query resolution techniques remotely and on site, and provides guidance to site staff as necessary, driving query resolution to closure within agreed timelines.</li><li>May perform Investigational Product (IP) inventory, reconciliation and reviews storage and security.</li><li>Verifies the IP has been dispensed and administered to subjects according to the protocol and verifies issues or risks associated with blinded or randomized information related to IP.</li><li>Applies knowledge of GCP and local regulations and organizational procedures to ensure IP is appropriately (re)labelled, imported, and released and returned.</li><li>Manages reporting of identified issues and manages follow up to resolution.</li><li>Documents activities via follow up letters, monitoring reports, communication logs, and other required project documents as per SOPs and CMP and SMP.</li><li>Ensures all activities are managed by site personnel who are appropriately delegated and trained.</li><li>Enters data into tracking systems as required to track all observations, ongoing status and assigned action items to resolution. For assigned activities, understands project scope, budgets, and timelines; manages site level activities and communication to ensure project objectives, deliverables and timelines are met.  (Must be able to quickly adapt to changing priorities to achieve goals and targets).</li><li>Reviews data entry timeliness in line with outlined requirements, missing pages, outstanding data queries, timelines for database locks.</li><li>Reviews site signature sheet and delegation of duties log to confirm any newly added or removed site staff are documented appropriately and the log is up to date. Where the site or Site Signature Sheet and Delegation of Duties Log indicates site personnel are no longer active on a study, review and assess training compliance with any new and updated training requirements (i.e., protocol amendment(s), etc.)</li><li>Conducts follow up for escalated adverse event monitoring (AEM) report queries.</li><li>Checks the site and external facilities, equipment, and supplies (clinical and non-clinical) continue to be adequate to conduct the trial and with their expiry dates (as applicable).</li><li>Checks site specific logs are complete and up to date (e.g., Site Visit Log, Screening and Enrollment Log, Signature Sheet and Delegation of Duties Log, Subject Identification Code List, IP Accountability Log).</li></ul>Collaboration<ul><li>Collaborates with primary Site Manager who will act as the primary liaison with site personnel.</li><li>Prepares for and attends Investigator Meetings and sponsor face to face meetings.</li><li>Participates in global clinical monitoring and project staff meetings (inclusive of client representation, as applicable) and attends clinic.</li></ul>Who are Parexel?Parexel supports clinical studies across the full range of therapeutic areas, and we have longstanding partnerships with a vast client base.We supported the trials of most of today’s top 50 best-selling drugs, but equally we enable more niche drug developments that are critical to the well-being of many patients.You’ll be an influential member of the wider team.What we are looking for in this roleFor every role, we look for professionals who have the determination and courage always to put patient well-being first. That to us is working with heart.Here are a few requirements specific to this advertised role.Skills<ul><li>Networking and relationship building skills. Ability to communicate effectively and appropriately with internal and external stakeholders.</li><li>Ability to adapt to changing technologies and processes. Effectively overcoming barriers encountered during the implementation of new processes and systems.</li><li>Excellent communication (verbal and written), presentation, and interpersonal skills relating to colleagues and associates, both inside and outside of the organization.</li><li>Identifies and builds effective relationships with investigator site staff and other stakeholders.</li><li>Proficiency in local language is required.</li><li>Fluency in English is required.</li></ul>EducationBachelor’s degree or Registered Nurse (RN) in a related field or equivalent combination of education, training, and experience.Not quite the role for you?Join Our Talent Community and we’ll reach out with job alerts when positions that match your career interests become available. We’ll also share periodic updates about the latest company news and events.Sign up today <a href="https://jobs.parexel.com/functional-service-provider" target="_blank" rel="noopener noreferrer">https://jobs.parexel.com/functional-service-provider</a>

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